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Povećan je rizik od sedacije i respiratorne depresije. Poznato je da fenobarbital indukuje CYP3A4 enzim i ubrzava metabolizam diazepama u jetri, što smanjuje efekat diazepama.Oštećena funkcija i sedacija se mogu javiti i narednog jutra i nekoliko dana kasnije posle primene leka. Pacijente treba upozoriti da uticaj na centralni nervni sistem mo
oralni kontraceptivi, jer mogu da uspore izlučivanje diazepama iz organizma i pojačaju njegovo dejstvo. Može doći do pojave probojnog krvarenja pri istovremenoj primeni, ali zaštita od trudnoće nije smanjena-ostaje efikasna,Zbog sličnosti oksidativnih procesa, diazepam kompetitivno inhibira metabolizam ketamina. Premedikacija sa diazepamom d